Visual Presentation of Data by Means of Box Plots
The authors explain how to construct box plots and how they can help you to learn more about your data.Date: Fri, 2005-04-01 (All day)Publish Start Date: Fri, 2005-04-01 (All day)read more
View ArticleHow Many Samples?
The sample size is determined by three factors: the size of the difference between the means that should be detected, the precision of the methods being compared and the significance levels at which...
View ArticleBenchmarking for Analytical Methods: The Horwitz Curve
Analytical chemists are concerned with the quality of their methods and results. An important question in this context is whether the precision of a newly developed and validated method is up to...
View ArticleClassifying Chromatographic Systems by Clustering
It would help to have a restricted set of chromatographic systems (CS) that together serve as potential starting points in method development.Date: Wed, 2006-02-01 (All day)Publish Start Date: Tue,...
View ArticleRobustness Tests
The robustness/ruggedness of an analytical procedure is a measure of its capacity to remain unaffected by small but deliberate variations in method parameters.Date: Sat, 2006-07-01 (All day)Publish...
View ArticleExperimental Design Approaches in Method Optimization
An experimental design can be considered as a series of experiments that, in general, are defined a priori and allow the influence of a predefined number of factors in a predefined number of...
View ArticleData-Handling Software for a GLP Environment: Development and Validation...
In a good laboratory practice (GLP) environment, data-handling software cannot be used until it is validated. This even applies to the most simple program that performs calculations or stores data. A...
View ArticleCalibration
Calibration refers to the process of determining the relation between the output (or response or signal) of a measuring instrument and the value of the input quantity or property. Depending on the...
View ArticleScreening Designs (Part 1) — Types and Properties
Screening designs are used to screen for important factors during method optimization or in robustness testing. Usually, two-level screening designs, such as fractional factorial and Plackett–Burman...
View ArticleScreening Designs (Part 2) Data Analysis
Screening for important factors during method optimization or in robustness testing involves two-level screening designs, such as fractional factorial and Plackett–Burman designs, as described in Part...
View ArticleAssessment of Accuracy in Chromatographic Analysis
The assessment of accuracy, which involves the estimation of precision and the determination of trueness, refers to the process of evaluating whether the results provided by analytical methods are...
View ArticleExtracting Information from Chromatographic Herbal Fingerprints
Herbs and their extracts are currently being used for preventive and therapeutic goals. Consequently, the identification and quality control of these natural products is becoming increasingly...
View ArticleEstimating Uncertainty
Estimating uncertainty has become one of the most important metrological concepts in analytical science over the last 15 years to such an extent that some authors consider a result useless or invalid...
View ArticleThe Limit of Detection
The concept of the limit of detection (LOD) has been, and still is, one of the most controversial in analytical chemistry. The multiple definitions and calculation methods proposed have contributed to...
View ArticleResponse Surface Designs Part 1 — Types and Properties
Experimental designs are used in method development and robustness testing and have been discussed in an earlier article.1 An experimental design is an experimental set-up that allows the simultaneous...
View ArticleResponse Surface Designs (Part 2) — Data Analysis and Multiresponse...
Part two of the column on response surface designs looks at data analysis and various approaches to simultaneously optimize multiple responsesDate: Tue, 2009-12-01 (All day)Publish Start Date: Fri,...
View ArticleMethod Development for Drug Impurity Profiling: Part 1
In this Practical Data Handling column, method development for drug impurity profiling is discussed.Date: Thu, 2010-04-01 (All day)Publish Start Date: Sat, 2010-04-24 (All day)Article sort author:...
View ArticleMethod Development for Drug Impurity Profiling (Part 2)
A systematic approach to developing drug impurity profiling methods.Date: Mon, 2010-11-01 (All day)Publish Start Date: Thu, 2010-11-18 (All day)Article sort author:...
View ArticleCommon Problems with Method Optimization in Pharmaceutical Analysis
The various steps of an experimental design-based approach are considered and the problems that arise from wrong choices are described.Date: Mon, 2011-08-01 (All day)Publish Start Date: Fri, 2011-08-12...
View ArticleVariable Selection and Reduction in Multivariate Calibration and Modelling
In multivariate calibration and modelling a model is built between a large data matrix containing many variables for each sample and the property of the sample.Date: Thu, 2011-12-01 (All day)Publish...
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